One in four of those infected with the Moderna or Pfizer Covid vaccines experienced an unintended immune response

One in four of those infected with the Moderna or Pfizer Covid vaccines experienced an unintended immune response

This breakthrough allowed scientists to create proteins in the body without the immune system attacking the vaccine.

It allows for fast, accurate and highly effective vaccines and has been the backbone of the Covid vaccine response.

It was thought that a simple modification of uridine did not cause any problems in the cells, but a team of researchers at the University of Cambridge’s Medical Research Council (MRC) Toxicology Unit have now found that when this partly synthetic code is read, the protein-making machinery in the body sometimes struggles with isotopes. Uridine.

Because it’s not exactly what’s expected, there can be a pause that causes the process to get stuck and a character in the code can be skipped, just like a bike slipping through a gear.

This process, called frameshifting, sheds light on the way code is interpreted because it relies on groups of three rules, known as codons, being read in the correct order.

This problem, caused by the poke code, causes the entire process to go out of sync and the entire subsequent code becomes garbled.

In the case of Covid vaccines, the team found that the end result is a nonsensical, harmless protein, which the body attacks and sets the immune system on fire. The new study, published in the journal Nature, found that this happens in about 25-30% of people.

Fear of the rogue protein

Scientists say the vaccine reads well enough to create strong protection against the coronavirus, but the tire-shifting problem creates what has been, until now, an unknown off-target effect.

The code relating to Covid vaccines was innocuous and no issues arose. However, the team says subsequent mRNA vaccines used for other diseases or infections could, in theory, create viable proteins that become active in the body.

In this scenario, not only does the vaccine not make the correct protein, it may produce a rogue protein.

The authors stress that there is no evidence of this happening in Covid vaccines, and say that any trials on other mRNA therapies will reveal any such problems in the early stages.

“Research has shown beyond doubt that the mRNA vaccine against COVID-19 is safe,” said Dr. James Thavinthiran, the report’s senior author. “Billions of doses of the Moderna and Pfizer mRNA vaccines have been delivered safely, saving lives around the world.

The researchers also found that there is an easy way to eliminate frameshift events that rely on changing the mRNA drug code to reduce the use of problematic pseudo-uridine.

Replacing it with a natural base which when read as a triplet still produces the correct amino acid is sufficient to stop unwanted skipping and thus improve safety without sacrificing efficacy.

Scientists say these findings were shared with the MHRA about a year ago, and updated vaccines using the improved form of mRNA are in the works for cancer vaccines and other treatments.

“Revolutionary technology”

“This technology is amazing and will be revolutionary as a new medical platform for all sorts of things, but we’ve made it safer going forward,” Professor Anne Willis, director of the Medical Research Centre’s toxicology unit, told reporters.

“Ribosomes somehow sense the modified RNA, but the Covid vaccines are very safe and very effective.

“But there are decoding issues in this technology that can cause stalling and tire shifting and we can get cellular immunity to these peptides after vaccination.”

However, she adds that it is very exciting that there is a way to fix the problem, which “significantly reduces the risks of this platform in the future.”

(Tags for translation)Standard

You may also like...

Leave a Reply

Your email address will not be published. Required fields are marked *