Common stomach bacteria found in two-thirds of the world’s population can increase the risk of developing Alzheimer’s disease

Common stomach bacteria found in two-thirds of the world’s population can increase the risk of developing Alzheimer’s disease

The concept of superbugs

Recent research from McGill University suggests a link between Helicobacter pylori (H. pylori) infection and an increased risk of Alzheimer’s disease in people aged 50 years and older. Analyzing health data from more than four million UK residents, the study found that those with symptoms of H. pylori infection had a greater risk of developing Alzheimer’s disease. This research underscores the importance of examining potential prevention strategies, including H. pylori eradication, to combat the increasing prevalence of Alzheimer’s disease globally.

The McGill study links a moderate but significant increase in the risk of Alzheimer’s disease in older adults with bacterial infections.

New research suggests that stomach bacteria found in two-thirds of the world’s population could be linked to an increased risk of cancer Alzheimer’s disease illness.

The study published in Alzheimer’s disease and dementia: Journal of the Alzheimer’s Association, investigated whether clinically apparent Helicobacter pylori (H. pylori) infection increases the risk of developing Alzheimer’s disease in people aged 50 years or older. Prevailing infection can lead to indigestion, gastritis, ulcers, and even stomach cancer.

A team of McGill University researchers analyzed health data for more than 4 million people in the United Kingdom aged 50 and over between 1988 and 2019. They found that people with symptoms of H. pylori infection had an 11% higher risk of developing Alzheimer’s disease, which is the most likely to develop Alzheimer’s disease. A common type of dementia. While the cause of Alzheimer’s disease is multifaceted, the findings build on a growing body of evidence about the potential role of infections, particularly Helicobacter pylori, in its development. The study opens up prospects for future research, particularly exploring whether eliminating these bacteria can effectively prevent Alzheimer’s disease in some people.

Implications for Alzheimer’s disease

Researchers say Alzheimer’s disease affects millions of people globally, and the numbers are expected to rise sharply with the demographic shift. “Due to the world’s aging population, the number of people with dementia is expected to triple over the next 40 years. However, there is still a lack of effective treatment options for this disease,” said Dr. Paul Brassard, senior author of the study and a professor in the Department of Medicine at McGill University. “.

“We hope that the results of this research will provide insight into the potential role of H. pylori in dementia in order to inform the development of prevention strategies, such as individualized eradication programs, to reduce infection at a population level,” Dr. Brassard said. , a public health and preventive medicine physician at McGill University Health Centre.

Reference: “Clinically evident Helicobacter pylori infection and risk of Alzheimer’s disease: a population-based, nested case-control study” by Antonius Doros, Zarmin Antti, and Carlo A. Vallone, Laurent Azoulay, Christel Renaud, Sammy Soissa, and Paul Brassard, December 13, 2023, Alzheimer’s disease and dementia.
doi: 10.1002/alz.13561

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