2023 NFL Week 1 Games: Betting odds, lines, picks, spreads, and more

The 2023 NFL season kicks off Thursday night with Patrick Mahomes and the defending Super Bowl champion Kansas City Chiefs hosting a rookie Detroit Lions team and their rebuilt backfield, featuring 2023 first-round pick Jahmir Gibbs and free agent signing David Montgomery.

There are fourteen more games on the list this Sunday, including the primetime showdown between the Dallas Cowboys and the New York Giants. Monday Night Football (ESPN, ABC, ESPN+) will feature the Super Bowl hopeful Buffalo Bills against Aaron Rodgers’ freshman team, the New York Jets.

Check back here daily for updated lines and information from ESPN Stats & Info.

Lines courtesy of Caesar Sportsbook. Football Strength Index (FPI) from the ESPN Sports Analytics suite.

First week games of the National Football League

Detroit Lions at Kansas City Chiefs (-6.5)
Thursdays at 8:20 p.m. ET, GEHA Stadium in Arrowhead Stadium, Kansas City, Missouri

Open favourites: Bosses (-6.5)
FPI favourites: Chiefs (66.2%)
money line: Lions (+250), Bosses (-320)
Total opening: 51.5 points
the total: 54 points

Carolina Panthers at Atlanta Falcons (-3.5)
Sunday at 1 p.m. ET, Mercedes-Benz Stadium, Atlanta

Open favourites: Falcons (-2)
FPI favourites: Falcons (55.9%)
money line: Panthers (+150), Falcons (-178)
Total opening: 39.5 points
the total: 39.5 points

Cincinnati Bengals (-2.5) at Cleveland Browns
Sunday, 1:00 p.m. ET, at First Energy Stadium, Cleveland

Open favourites: Bengals (-1)
FPI favourites: Bengals (59.2%)
money line: Bengal (-140), Brown (+118)
Total opening: 46.5 points
the total: 47.5 points

Jacksonville Jaguars (-5) at Indianapolis Colts
Sunday at 1 p.m. ET, Lucas Oil Stadium, Indianapolis

Open favourites: Jaguar (-3)
FPI favourites: Jaguar (64.5%)
money line: Jaguars (-225), Colts (+185)
opening total: 43 points
the total: 45 points

Tampa Bay Buccaneers at Minnesota Vikings (-6)
Sunday, 1:00 p.m. ET, at US Bank Stadium, Minneapolis

Open favourites: Vikings (-6)
FPI favourites: Vikings (67.1%)
money line: Pirates (+210), Vikings (-260)
opening total: 45.5 points
the total: 45.5 points

Tennessee Titans at New Orleans Saints (-3)
Sunday, 1:00 p.m. EST, Caesars Superdome, New Orleans

Open favourites: Saints (-3)
FPI favourites: Saints (53.4%)
money line: Titans (+140), Saints (-165)
Total opening: 41 points
the total: 40.5 points

San Francisco 49ers (-2.5) at Pittsburgh Steelers
Sunday, 1:00 p.m. ET, at Accresor Stadium, Pittsburgh

Open favourites: 49ers (-2.5)
FPI favourites: 49ers (55.9%)
money line: 49ers (-135), Steelers (+115)
Total opening: 41 points
the total: 41 points

Arizona Cardinals at Washington Commanders (-7)
Sunday at 1 p.m. ET, FedEx Field, Landover, Maryland

Open favourites: Leaders (-5.5)
FPI favourites: Leaders (63.8%)
money line: Cardinals (+250), Leaders (-320)
Total opening: 40.5 points
the total: 38 points

Houston Texans at Baltimore Ravens (-10)
Sunday, 1:00 p.m. ET, at M&T Bank Arena, Baltimore

Open favourites: Crows (-10)
FPI favourites: Crows (73.5%)
money line: Texas (+360), Ravens (-480)
Total opening: 43.5 points
the total: 43.5 points

Green Bay Packers at Chicago Bears (-1)
Sunday, 4:25 p.m. ET, Soldier Field, Chicago

Open favourites: Bears (-1)
FPI favourites: Bears (51.5%)
money line: Packers (-105), Bears (-115)
Total opening: 41.5 points
the total: 43 points

Las Vegas Raiders at Denver Broncos (-3.5)
Sunday, 4:25 p.m. ET, Empowerment Field in Mile High, Denver

Open favourites: Broncos (-3)
FPI favourites: Bronco (59.1%)
money line: Raiders (+158), Broncos (-190)
Total opening: 44.5 points
the total: 44 points

Philadelphia Eagles (-4) at New England Patriots
Sunday at 4:25 p.m. ET, Gillette Stadium, Foxboro, Massachusetts

Open favourites: Eagles (-3.5)
FPI favourites: Al-Nusour (61.9%)
money line: Eagles (-195), Patriots (+162)
Total opening: 45 points
the total: 45 points

Miami Dolphins @ Los Angeles Chargers (-3)
Sunday at 4:25 p.m. ET, Sophie Stadium, Englewood, California

Open favourites: Chargers (-2.5)
FPI favourites: Chargers (55.4%)
money line: Dolphins (+140), Chargers (-165)
Total opening: 48.5 points
the total: 51 points

Los Angeles Rams vs. Seattle Seahawks (-5)
Sunday at 4:25 p.m. ET, Lumen Field, Seattle

Open favourites: Seahawks -4
FPI favourites: Seahawks (62.7%)
money line: Rams (+196), Seahawks (-240)
Total opening: 46.5 points
the total: 45 points

Dallas Cowboys (-3.5) at New York Giants
Sunday at 8:20 pm Egyptian time MetLife Stadium, East Rutherford, New Jersey

Open favourites: Cowboy (-2.5)
FPI favourites: Cowboys (55.3%)
money line: Cowboys (-170), Giants (+143)
Total opening: 45.5 points
the total: 46.5 points

Buffalo Bills (-2.5) at New York Jets
Mondays at 8:15 p.m. ET, MetLife Stadium, East Rutherford, New Jersey

Open favourites: Invoicing (-1)
FPI favourites: Invoices (57.6%)
money line: Bills (-145), Jets (+122)
Total opening: 46.5 points
the total: 46.5 points